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Research has also suggested that vitamin B12 is critical in synthesizing neurotransmitters such as dopamine and serotonin, which are involved in mood regulation and cognitive function

The MHRA advises periodic monitoring of B12 levels in at-risk or symptomatic patients taking metformin

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[126] Cellular reprogramming [edit] Vitamin B 12 through its involvement in one-carbon metabolism plays a key role in cellular reprogramming and tissue regeneration and epigenetic regulation