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Targeted Degradation of Transcription Coactivator SRC1 through the NDegron Pathway

Since the net charge of CAND is -0.2, resulting in an overall neutral charge, it is difficult for CAND to be effectively transported to the cell nucleus on its own

The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions