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The landmark Rudman study demonstrated that GH therapy in older men produced an 8.8% increase in lean body mass and a 14.4% decrease in adipose tissue over six months (6)

While effective in raising HGH, injecting the hormone itself can suppress the bodys natural production and lead to side effects such as swelling, joint pain, and, in some cases, increased risk of diabetes or certain cancers

In addition, hypoinsulinemia in T1DM stimulates hepatic synthesis of IGFBPs, resulting in increased IGF-binding capacity and, consequently, reduced IGF-1 bioactivity which further stimulates GH-secretion [190192]

Studies indicate that without intervention, up to 25% of weight lost during aggressive dieting comes from lean muscle mass rather than fat