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In addition, VGB4 inhibited VEGF-A-induced sprouting angiogenesis in collagen matrix with the maximum reduction effect on sprout number by 67.5% and 84.1% at 0.55 M and 0.74 M, respectively, as compared to control and scr ( P 0.001) (Fig

The overlap in anti-fibrotic and anti-oxidative pathways strengthens the biological plausibility of MSC-based rejuvenation, yet the two studies diverge on safety assumptions