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The currently available drugs for the treatment of these diseases often have significant adverse effects, particularly those used in long courses of treatment, ranging from relatively mild (such as nausea or loss of appetite) to severe (such as nephrotoxicity or peripheral neuropathy) (183186)

The novel Lyme borreliosis vaccine VLA15 shows broad protection against Borrelia species expressing six different OspA serotypes

Mammalian erythrocytes on the other hand modulate the innate immune response through generation of reactive oxygen species (ROS) to promote inflammatory and autoimmune response against invading microorganisms [108]