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Some users report needing 20-50% higher nasal doses to achieve equivalent effects, though individual variation is substantial

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Anti-Doping Agency (USADA). It falls under Category S2: Peptide Hormones, Growth Factors, Related Substances, and Mimetics on the WADA Prohibited List, often specified as a "Growth Hormone Releasing Hormone (GHRH) and its analogues" or a "Growth Hormone Secretagogue (GHS)". The ban is due to its potential to unfairly enhance athletic performance by increasing muscle mass, strength, reducing fat, and improving recovery. The prohibition applies regardless of its mechanism of stimulating endogenous GH, as the outcome of artificially elevated GH/IGF-1 is the concern