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Previous studies suggested that RT rewires cancer metabolism through an altered glycolysis 18 and pentose phosphate pathway 19 to deal with radiation-induced hypoxia and DNA damage, respectively

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In pediatric patients, 1 - 3 mEq/kg infused over 4 - 8 hours is customary, but neonates should receive 4.2 % solutions at rates no greater than 8 mEq/kg/day to avoid intracranial hemorrhage