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Endogenous IL-1 has been reported to be insufficient for activating and recruiting neutrophils, and even high pharmacological doses of IL-1 fail to exacerbate APAP-induced liver injury, indicating that IL-1 signaling is not a critical contributor to APAP-induced hepatotoxicity

doi: 10.3390/biom9080356

solution-format research, concentration comparison, formulation and handling studies

Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation