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A rare case involved a woman who had immediate adverse reactions to both cyanocobalamin and hydroxocobalamin, by both injection and oral delivery

Another neuronal-targeting peptide, Ten Eleven Translocation one (Tet-1), derived from tetanus toxin, binds to tri-sialo-ganglioside receptors located on the surface of motor neurons and has been used successfully to deliver therapeutic agents to neurons in several models (87)

Animal models of asthma have indicated that the expression of the clock gene BMAL1 plays a role in eosinophil trafficking and the production of the cytokine IL-5 [23], which is a target of multiple asthma drugs and has been shown to be under epigenetic regulation [24]