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Relative to the conversion in human plasma, the percent conversion values of 7-HMG to unknown-1 in mouse, rat, dog, and monkey plasma were 3.7 0.0, 4.4 0.3, 3.2 0.0, and 8 0.0% (mean SD), respectively

Other, more indirect strategies have evolved to translate cAMP signals into changes in POMC gene expression involving a CREB/c-Fos/AP-1 signaling cascade activating POMC transcription via an activator protein-1 (AP-1) site in exon 1