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Long-term use of NSAIDs may lead to side effects on the cardiovascular system, gastrointestinal tract, and kidneys, such as increased risks of heart disease, indigestion, gastrointestinal ulcers, bleeding, and reduced kidney function

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Future research should prioritize personalized VNS therapies, leveraging closed-loop systems integrated with multimodal biomarkers (e.g., EEG-gated taVNS) to dynamically optimize stimulation in real-time (123)

Persistent symptoms should trigger a review of dose, hydration, sleep, and product quality