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It may affect small, localised areas of the body, such as the scalp, arm, or leg, or it can spread to involve larger regions or even the entire body

Several factors predict how severe the loose skin issue will be: total amount of weight lost, speed of the loss, age of the individual, genetics, smoking history, sun damage history, and whether the person has previously gained and lost large amounts of weight (the so-called yo-yo effect)

However, the inhibitory effect of NPW on MPO activity and NPW-induced increase in GSH content were not observed when NPW injections were preceded with either the selective COX-1 inhibitor ketorolac or the non-selective COX-inhibitor indomethacin, but the effects of NPW were not altered by the COX-2 inhibitor NS-398

Alcoholic liver disease: mechanisms of injury and targeted treatment