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All treatment conditions were performed with four replicates

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Fluorescence was observed 3 dpi

In H3122 xenograft model, treatment with W4@cRGD-LPs (5 mg/kg) and Z2@cRGD-LPs (4.34 mg/kg) every two days led to 77.4% tumor growth inhibition, accompanied by a 30-fold higher intratumoral concentration of WZ42 compared to the unformatted control