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two: 10.1038/ejcn.2017.132

Despite the fact that nuclear translocation of MLKL is not essential for execution of necroptosis, it can still facilitate this RCD [150]

Furthermore, seen in HNSCC were exosomes formed from M1-containing lncRNA HOTTIP were discovered to control the TLR5/NF-B signaling pathway, hence promoting cancer cell death and preventing migration