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Furthermore IGF-Is antioxidant capability in brain cortex and hippocampus was assessed as improving antioxidant enzymes activities (superoxide dismutase, catalase and glutathione peroxidase) and parameters of oxidative damage (MDA and PCC)[55, 56]

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4.1 Resistance to inhibitors of glutamine metabolism Due to the plasticity of tumor cell metabolism, tumor cells evolved an adaptive metabolic network in the absence of glutamine supply