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This could be attributed to sulfasalazine-induced nephrotoxicity, as sulfasalazine is known to induce crystalluria and accumulation of reactive oxygen species in the kidney

J Prot Res 10:25902601 Rmheld V (2012) Chapter 11diagnosis of deficiency and toxicity of nutrients

The phrase "most effective" reflects positioning language used in competitive marketing contexts and does not represent a clinically established comparative conclusion