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Taken together, these findings indicate a time-dependent interaction between corticosteroids and stem cell-based therapies: short-term local corticosteroid exposure may synergize with MSC-mediated immunoregulation, whereas prolonged systemic corticosteroid use may impair MSC licensing by suppressing critical inflammatory signals such as IFN-

However, in individuals with preexisting neoplastic conditions, excessive intake, particularly of synthetic folic acid, may increase cancer risk, although this relationship remains to be fully elucidated (61)