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The anti-CD47 antibody (B6H12) showed that CD47 plays a critical role in immune system evasion and the process of metastasis because the antibody boosted macrophage phagocytosis, while CD47 blockade failed to stop tumor cell death and their normal cell functions 128

Zhang K, Chen D, Ma K, Wu X, Hao H, Jiang S (2018a) NAD(P)H: quinone oxidoreductase 1 (NQO1) as a therapeutic and diagnostic target in cancer

doi: 10.1016/j.jep.2023.116506 83 WangSZhaoYYaoFWeiPMaLZhangS

The co-occurence of two highly diverged paralogs of AsGSTe2 in Alw-R, which are already present in different populations, indicates that the inclusion of two diverged paralogs of AsGSTe2 in Alw-R is most likely through recombination of two diverged strains, not through sequential evolution of duplicated AsGSTe2