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Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator

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doi: 10.1111/ene.12599 112

The demonstrated importance of protecting the terminals to pharmacokinetic characteristics suggests numerous additional synthetic approaches that may be applicable including the insertion of non-peptide linkages between the first and second amino acids, the replacement of the N~terminal amino acid with a non-a amino acid, and N-terminal acylation