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Compared to STZ treatment alone, addition of SFN decreased nephromegaly, glomerular collagen accumulation, glomerulosclerosis, glomerular basement membrane thickness, and urine albumin excretion, but only in wild-type mice [50]

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Back to Journals Drug Design, Development and Therapy Volume 18 The Protective Effect of Roflumilast Against Acute Hepatotoxicity Caused by Methotrexate in Wistar Rats: In vivo Evaluation Authors Almalki RS Received 19 October 2023 Accepted for publication 9 February 2024 Published 15 February 2024 Volume 2024:18 Pages 453462 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Anastasios Lymperopoulos Riyadh S Almalki Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm AL-Qura University, Makkah, Saudi Arabia Correspondence: Riyadh S Almalki, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm AL-Qura University, Makkah, 23335, Saudi Arabia, Email [email protected] Introduction: Methotrexate (MTX) is one of the most widely used drugs in cancer chemotherapy and treating rheumatoid arthritis