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Collectively, these studies imply mutant ALS proteins produce inflammatory cytokines, disturb redox homeostasis, and increase neuroinflammation and toxicity

Common contributing factors include: repetitive movements of the hands and wrists, prolonged flexion or extension of the wrist, main ailments, hormonal changes genetic predisposition

India Environ Health Perspect 108(5):393397

Since L-cysteine is the rate-limiting amino acid in glutathione synthesis, an NAC supplement is a bioavailable cysteine donor that can increase cellular glutathione levels