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Labels such as psychogenic or psychosomatic are applied by doctors, in part, because of a statistical correlation with higher levels of depression and anxiety.[ref] However, the physiological and cellular changes in people with chemical sensitivities are measurable, statistically significant, and visible, strongly suggesting a physiological cause rather than a psychological cause.[ref][ref] On the other hand, there are several clinical trials using specific solvents or chemical odors that found no statistical change in measured parameters (e.g

400,401 Oxidative stress can cause the oxidation of tyrosine-protein kinase Fyn at Cys488, leading to the initiation of the Ras/Raf/MEK/ERK cascade

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