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This is mechanistically distinct from proton pump inhibitor pharmacology and is part of why the peptide attracts interest as a research tool for ulcer biology and NSAID-induced gastric injury

Translates partially to human RGN-259 trials though those focused on cornea not retina

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Currently, celecoxib is being investigated to determine its efficacy in the inhibition of radiotherapy-induced cytokine release associated with metastasis development in triple-negative breast cancer patients (NCT07104266) [295]