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Adaptive changes in fatty acid desaturation genes in indigenous populations of Northeast Siberia

12,2530 Various mechanisms underlying development of NAFLD The cellular and immunological mechanisms underlying the development of NAFLD toward NASH might include endoplasmic reticulum stress, 32 mitochondrial dysfunction, 33 lipotoxicity, and the release of pro-inflammatory cytokines responsible for liver inflammation, such as TNF-, interleukin (IL)-6, leptin, and resistin in enhanced amounts and decreased secretion of adiponectin