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In particular, Trastuzumab emtansine (Kadcyla, T-DM1) that comprises an HER2-targeted antibody, a non-cleavable linker and a microtubule disrupting agent as the payload, and Trastuzumab deruxtecan (Enhertu, T-DXd), which is composed of a HER2-targeted antibody, a cleavable linker and a Topoisomerase I inhibitor as payload

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This superoxide is rapidly converted into hydrogen peroxide (HO), which, in the presence of Fe 2+ , generates highly reactive hydroxyl radicals (OH) through the Fenton reaction