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Stop or reduce any movement that causes symptoms to spread farther into the hand, become sharper, or remain worse afterward

Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes

Nature Reviews Endocrinology, 9 (6), 357-365

It is no surprise that growth hormones are an essential part of human development, but as people age, their growth hormone levels decline, and so do things such as muscle growth, metabolism, brain function, energy production, and much more