glutathione-s-transferase conjugated p53 Glutathione S-transferase in complex with platinum and ethacrynic acid Hypermethylation of the glutathione S-transferase

Other pathways could also be involved in cardiac injury due to iron overload

317 Moreover, SESTRIN2 expression is upregulated by UVA exposure (315400 nm) via mitochondrial ROS, and its absence inhibits UVA-induced ROS production

Although in vitro and in vivo preclinical studies have demonstrated the therapeutic potential of these metabolites, further validation through animal models and subsequent clinical trials is required to provide robust evidence (206)

Human umbilical cord mesenchymal stem cell-derived extracellular vesicles harboring IGF-1 improve ovarian function of mice with premature ovarian insufficiency through the Nrf2/HO-1 pathway