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Patient Management and Practical Recommendations Pre-Treatment Tests B12 and Biomarker Panel: Baseline blood tests checking Vitamin B12, Folate, Methylmalonic Acid (MMA), and Homocysteine levels to confirm the exact type and severity of the deficiency

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These anti-inflammatory effects parallel our pharmacogenomics strategy, indicating that leucovorin downregulates the gene coding for Interferon gamma ( IFNG ), a key inflammatory cytokine, and our results in adult remyelinating lesions indicating that leucovorin acts in microglia/macrophages accelerating the transition from pro-inflammatory to pro-regenerative profiles