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A subset of cells located at the perimeter of the blood islands, termed angioblasts give rise to precursors for endothelial cells, while those at the center differentiate to hematopoietic cells

According to a recent paper in the Journal of Clinical, Cosmetic and Investigative Dermatology, three factors are thought to contribute to dark circles under eyes: hyperpigmentation, a tendency for more dilated, thicker or increased number of capillaries and thinner skin in the under-eye area