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Curr Opin Toxicol 9:2834 Yu R, Lai Y, Hartwell HJ et al (2015) Formation, accumulation, and hydrolysis of endogenous and exogenous formaldehyde-induced DNA damage

Concurrently, IVDD triggers an inflammatory cascade, where factors such as interleukin-1 beta (IL-1) and tumor necrosis factor-alpha (TNF-) overactivate matrix metalloproteinases (MMPs), accelerating the degradation of collagen II (COL2) and aggrecan (ACAN) (Pan et al., 2023

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