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The exposure runs deeper than one compound

Th17 cells, whose proliferation is closely connected to gut dysbiosis, produce IL-17 A and GM-CSF, which not only activate microglia but also damage the BBB by acting on endothelial IL-17RA, resulting in a self-reinforcing permeability loop

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This is because the model is created by directly injecting MSU into the joint cavity, which does not mimic the natural induction of gout by UA saturation in the body, making it challenging to conclusively determine if PDA@Pt can treat acute gout by breaking down UA