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Many studies have found that reflux does not directly damage the esophageal epithelium, but stimulates the secretion of inflammatory chemokines by the epithelial cells, which induces proliferative changes in the epithelium and recruitment of inflammatory cells such as T lymphocytes, which in turn leads to the damage of the esophageal epithelium

Protein purification Prior to each protein analysis the target protein has to be separated from a complex mixture to focus on the function without influences from other molecules, making protein purification to one of the main applications in biotechnology

Biologics, such as monoclonal antibodies against proinflammatory cytokines like IL-4, IL-5, IL-13, and IgE, have also been tried

StenvallJ.Fierro-GonzalezJ