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Impact on sirtuins and cellular repair NAD+, NR, and aging are connected through sirtuin activation

Key Takeaway Consistent supplementation, adequate Vitamin C intake and reducing lifestyle factors that increase oxidative stress may all help support healthy glutathione levels over the long term

This has implications for how to design human albumin-fused biologics, as QMP engineering may ensure a long plasma half-life, increased target exposure, and enhanced efficacy, despite potential C-terminal cleavage post-administration

Aided by a novel crystal system of TRF1 TRFH , we characterised fragments binding in a hotspot at the TRF1:TIN2 interface