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Journal of Research in Applied and Basic Medical Sciences 10: 191-204 (2024) Tsiasioti A, Zotou AS, Tzanavaras PD

The root cause of IBD pathogenesis involves a disruption in the equilibrium between T helper (Th) cells and regulatory T cells, emphasizing the inability of regulatory T cells to function effectively.CD is characterized by inflammation driven by Th1 cells, resulting in an overproduction of IL-12, IL-17, and IL-23 (65)

Combined KRAS G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS G12C -driven cancers by addressing intrinsic and acquired resistance

Yet, these organs are still susceptible to sustained inflammation insults, particularly those that can result in widespread systemic inflammation