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Note that the therapeutic indication for all of these drugs is for type 2 diabetes, with the exception of Wegovy (2.4 mg/week of semaglutide by subcutaneous injection), which was recently approved for weight loss

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in vitro ( Materials and Methods Animals Specific pathogen-free male C57BL/6 mice were purchased from Liaoning Changsheng Biotechnology Company (Benxi, China) and were maintained under controlled conditions (indoor temperature: 22 1C and humidity: 40 60%) and a 12-h dark-light cycle