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Development and optimisation of alternative methods and approaches Main gaps identified: high rate of misleading/false genotoxic positives Existing in vitro methods, whilst having a high sensitivity (and thus low false negative rate), have a relatively low specificity and thus high rate of false (misleading) positive results, which typically has led to unnecessary follow-up testing in vivo for the confirmation of these results

After testing the biochemical parameters of each organ, organ indices were calculated and histomorphological changes were monitored

Miernikiewicz, P

Typically, after approximately four treatment sessions spaced 4-6 weeks apart, patients will begin to see the full effects of the PRP therapy about five to six months after starting treatment