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Description

In the process of oxidative phosphorylation, complex I (NADH quinone oxidoreductase) acts as the entry point for electrons from the mitochondrial matrix into the electron transport chain (ETC) by catalyzing the electron transfer from NADH into the ETC subunits 22

Therefore, recruiting the right type of F-box protein at the right time is essential for proper SCF function, and how the cellular repertoire of SCFs is dynamically controlled to meet the needs of a cell to target a changing pool of substrates for ubiquitination has been a critical question