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Apremilast, a phosphodiesterase 4 inhibitor, offers a safer hepatic profile but has lower efficacy than traditional systemic agents

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Bio-Rad was used to transfect the brain slices with a human htt exon-1 expression construct containing a 73 CAG repeat (HttN90Q73) in the gWiz backbone (Genlantis) together with a YFP expression construct to visualize transfected neurons