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There have been reports of depression, mania, psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide in patients attempting to quit smoking while taking CHANTIX [see WARNINGS AND PRECAUTIONS ]

FerkolTWFarberHJLa GruttaSLeoneFTMarshallHMNeptuneEet alElectronic cigarette use in youths: a position statement of the forum of international respiratory societies

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This increase in testosterone levels appears to be dose-dependent, meaning that the more cigarettes smoked daily, the higher the testosterone levels tend to be