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Furthermore, evidence shows that most (up to 95%) pharmaceutical drugs found effective and safe in animal studies fail in subsequent clinical phases in human populations, mainly due to insufficient efficacy, toxicity, and the emergence of unacceptable adverse drug reactions, raising significant concerns for ethical and economic reasons (204211)

Thirty-two participants completed Phase I, of whom 29 (90.6%) were classified as high-TMAO producers ( 5 mol/L and 50% increase from baseline to 24-h follow-up)

Its not a treatment for clinical anxiety disorders, but it addresses the nutritional depletion that chronic stress and anxiety create

For example, NSAIDs such as ibuprofen cannot be used for long periods of time because they increase the risk of stomach bleeding and heart attack