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doi: 10.1038/ni.3023 93 SutherlandTERckerlDLoganNDuncanSWynnTAAllenJE

To understand further, we observed the induction of mitochondrial genes Bax, and thus involving intrinsic pathways of apoptosis

sALS and fALS progression is clinically and pathologically very similar, both characterized by the progressive accumulation of toxic misfolded protein aggregates within cells [76] and the significant loss of MNs [77]