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This article is another great example of that

Modified NAD and glutathione metabolism is associated with a number of diseases, but no data exist of how specific pathology is shifting blood redox profile

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At the same time, iron-dependent lipoxygenase (LOX) catalyzes polyunsaturated fatty acids (PUFAs) to induce OS, which further alters the permeability of BBB (Iadecola and Anrather 2011)