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Guidance for industry: applications for premarket review of new tobacco products draft guidance

[141] A 2015 Public Health England report stated that "Smokers who have tried other methods of quitting without success could be encouraged to try e-cigarettes (EC) to stop smoking and stop smoking services should support smokers using EC to quit by offering them behavioural support." [142] However, since little is known about long term effects, other regulated options such as nicotine replacement therapy, varenicline or bupropion should be discussed primarily

obtained from Knigshofer Futtermittel (Ebergassing, Austria)) and received water ad libitum