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Despite their efficacy, betablockers can be associated with significant adverse effects

Zague V, de Freitas V, Rosa M C, et al

Increased vascularization supports nutrient delivery and waste removal, which are important for oocyte quality and embryo implantation

Besides, saikosaponin A activates IL-12/STAT4 pathway to increase serum IFN- and IL-12 levels and decreases in serum IL-4 and IL-10 levels, which shift Th1/Th2 balance toward Th1 [259]