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However, the finding that mutation of a single aminoacid residue can drastically alter the substrate specificity and other characteristics (Norrgrd et al., 2006) makes these criteria less conclusive for GST class assignments

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Histamine acts as a neurotransmitter involved in the contractions of the intestinal muscles.[ref] People with food allergies and IBS had significantly higher levels of H1 and H2 receptors in their intestines.[ref] Histamine receptors in the brain: A 2026 study explored the role of histamine and histamine receptors in different regions of the brain