Additionally, neutrophils contribute to liver regeneration by producing hepatocyte growth factor, which is essential for hepatocyte proliferation and tissue repair in patients with AH.52 One key regulator of neutrophil function in ALD is miR-223, which is highly expressed in neutrophils and acts as a critical modulator of inflammation and liver injury.51 53 miR-223 limits alcohol-induced liver damage by inhibiting the IL-6-phagocytic oxidase 47 (p47 phox ) pathway, which is involved in ROS production and neutrophil activation.51 In mouse models, the deletion of miR-223 exacerbates liver injury, indicating its protective role in ALD.51 By dampening excessive neutrophil activation and reducing ROS-mediated hepatocyte damage, miR-223 represents a potential therapeutic target for mitigating neutrophil-driven liver injury in ALD.51 It is well-known that IL-8 and neutrophils are elevated in patients with AH
Aboudalle I, Kantarjian HM, Ohanian MN, Alvarado Y, Jabbour EJ, Garcia-Manero G, Naqvi K, Wierda WG, Daver NG, Burger JA, Konopleva MY, Takahashi K, Andreeff M , Pemmaraju N, Ferrajoli A, Borthakur G, Kadia TM, Ravandi F, Cortes JE
Google Scholar Patnaik MM, Wassie EA, Lasho TL, Hanson CA, Ketterling R, Tefferi A
M.GroegerD
