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Compared with the current Cas9 nuclease-based approach, adenine base editors introduce point mutations more precisely and efficiently because of decreased off-target genome modifications and the absence of DNA cleavage

Experimental studies have shown that dietary supplementation with ketone esters or low-percentage fat enrichment can restore locomotor rhythmicity, normalize expression of SIRT1 and core clock genes, and ameliorate neurodegeneration [53]

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