Disclosures: Stuart Forbes: Resolution Therapeutics: Founder, Resolution Therapeutics: Founder, Paul Brennan: Resolution Therapeutics: Independent Contractor, Takeda: Speaking and Teaching, Mark Macmillan: Nothing to Disclose, Thomas Manship: Nothing to Disclose, francesca moroni: Nothing to Disclose, Alison Glover: Nothing to Disclose, Debbie Troland: Nothing to Disclose, Iain MacPherson: Nothing to Disclose, Catriona Graham: Nothing to Disclose, Scott Semple: Nothing to Disclose, David Morris: Nothing to Disclose, Alasdair Fraser: Nothing to Disclose, Chloe Pass: Nothing to Disclose, Neil McGowan: Nothing to Disclose, Lynn Manson: Nothing to Disclose, Marc Leighton Turner: Nothing to Disclose, Neil Lachlan: Nothing to Disclose, John Dillon: Gilead: Speaking and Teaching, Abbvie: Speaking and Teaching, Alastair Kilpatrick: Nothing to Disclose, John Campbell: Resolution Therapeutics Ltd: Advisor, Resolution Therapeutics Ltd.: Stock privately held company, Jonathan Fallowfield: Stimuliver: Advisor, Ipsen: Advisor, Kynos Therapeutics: Advisor, Resolution Therapeutics: Consultant, River 2 Renal Corp.: Advisor, Global Clinical Trial Partners: Advisor, Guidepoint: Consultant, GlaxoSmithKline: Grant/Research Support, Genentech: Grant/Research Support, Intercept Pharmaceuticals: Grant/Research Support, Stuart Forbes: Resolution Therapeutics: Founder, Resolution Therapeutics: Founder 2649 PERFORMANCE OF THE CAGE-B AND SAGE-B SCORES FOR PREDICTION OF HEPATOCELLULAR CARCINOMA IN CHRONIC HEPATITIS B PATIENTS WITH ADVANCED FIBROSIS Lesley Patmore 1 Lilian Yan Liang 2 Mai Kilany 3 Arno Furqium d'Almeida 4 Vincent Wong 5 Thomas Vanwolleghem 6 Pieter Honkoop 7 Hans Blokzijl 8 zgr Muhammet Koc 9 Harry Janssen 10 Matthijs Kramer 9 Joep de Bruijne 11 Apichat Kaewdech 12 Robert De Man 6 Bart Takkenberg 13 Grace Lai-Hung Wong 2 Jordan Feld 3 Milan Sonneveld 6 , 1 Erasmus MC, University of Rotterdam, 2 The Chinese University of Hong Kong, 3 Toronto General Hospital, 4 Antwerp University Hospital, 5 The Chinese University Hong Kong, 6 Erasmus University Medical Center, 7 Albert Schweitzer Hospital, 8 UMC Groningen, 9 Maastricht UMC+, 10 Erasmus MC, 11 UMC Utrecht, 12 Prince of Songkla University, 13 Amsterdam University Medical Centers, location AMC Background: Patients with chronic hepatitis B (CHB) treated with nucleo(s)tide analogues (NA) remain at risk for hepatocellular carcinoma (HCC)

These consist of: Pernicious anaemia - In the UK, pernicious anaemia is the most common trigger for vitamin B12 deficiency
Here, we identified a chorismate mutase (Cm) effector SsCm1 by screening virulence-related secreted proteins (SsVSPs)
Longer studies (1 year) showed 43.8% fewer flare-ups and improved lung flow by nearly 97% (NIH)