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Eltrombopag was administered at an initial dose of 50 mg once daily for 2 weeks and increased over 2-week periods up to a maximum dose of 150 mg once daily

10.1016/j.jhep.2013.12.019 6 BaraonaE.LieberC

Thus, the killing of MB cells is the result among positive and negative signals transduced by activating or inhibiting receptors upon binding with the corresponding ligands on MB cells ( Figure 2 )