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While tamoxifen is highly effective in the management and prevention of breast cancer, yet, it may provoke adverse reactions including hot flushes, vaginal bleeding, endometrial polyps, and hyperplasia, and less common endometrial tumor, pulmonary embolism, stroke, porphyria, and liver injury 9,10,11,12

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Because its beta subunit binds to the exact same transmembrane LH/CG receptors found on target cells, researchers utilize it to bypass standard hypothalamic-pituitary-gonadal (HPG) axis signaling and directly observe downstream cellular responses